American Cuisine
Roast Beef and Cheddar Panini
By Maria Chen, RecipeOK Test Kitchen
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The panini press turned into a diner-counter fixture across the U.S. in the 1990s, but the combination pressed inside it — sliced roast beef, sharp cheddar, and something creamy with a bite — goes back much further, to the classic deli steak sandwich shops of the Northeast built their reputations on. Roast beef and cheddar is a natural pairing: the cheese's tang cuts through the richness of the beef, while a swipe of horseradish mayo adds the same peppery lift you'd get from a jus or au jus dip, without the mess of a dunk sandwich. Caramelizing the onions low and slow is what elevates this from a quick lunch to something worth savoring — the sugars in the onion break down into a deep, almost jammy sweetness that balances the horseradish's sharp edge. Sourdough is the unsung hero here: its natural tang and sturdy crumb hold up to the press without turning soggy, and it crisps into shards of golden crust that shatter satisfyingly with the first bite. This sandwich shows up constantly in American lunch counters and home kitchens alike because it hits every craving at once — savory, tangy, sweet, and crunchy — in under half an hour, making it a reliable answer to the eternal weeknight question of what to make with deli meat in the fridge and a block of cheddar going soft.
Ingredients
Serves 2Instructions
- 1
Gather and prepare all ingredients as specified in the ingredient list.
- 2
In a skillet with a little butter, sauté the onion slices over medium-low heat until caramelized, about 10-15 minutes.
- 3
Mix mayonnaise and horseradish in a small bowl.
- 4
Spread the horseradish mayo on the inside of the bread slices.
- 5
Assemble sandwiches with roast beef, caramelized onions.
- 6
Cheddar cheese.
- 7
Grill on a panini press or in a skillet until bread is crispy and cheese is melted.
Chef's Tips
- ✦ Caramelize the onions well ahead of time (even a day before) — they reheat perfectly and you won't be tempted to rush them on sandwich night.
- ✦ Butter the outside of the bread rather than the pan for the most even, deeply golden crust in a skillet or panini press.
- ✦ Press with a heavy pan or bacon press if you don't own a panini maker — even weight is what gets the cheese fully melted before the bread burns.
- ✦ Let the panini rest for 1-2 minutes off the heat before slicing so the melted cheese sets slightly and doesn't run out the sides.
Ingredient Substitutions
-
sourdough bread → rye or ciabatta
rye adds extra tang; ciabatta gives a chewier crust
-
sharp cheddar cheese → provolone or Swiss
milder, meltier options if you want less bite
-
prepared horseradish → Dijon mustard
swap 1:1 for a milder, still-tangy spread
-
deli roast beef → leftover pot roast, thinly sliced
great way to use holiday leftovers
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Frequently Asked Questions
Can I make this sandwich without a panini press? ▼
Yes. Use a regular skillet over medium-low heat and press the sandwich down firmly with a second heavy pan or a wrapped brick for 3-4 minutes per side until golden and the cheese has melted.
What's the best way to reheat leftover roast beef for this sandwich? ▼
Warm sliced roast beef briefly in a dry skillet or in the microwave with a damp paper towel over it for 20-30 seconds; overheating deli roast beef makes it tough and dry, so keep it just until warmed through.
Can I use raw roast beef instead of deli-style pre-cooked slices? ▼
This recipe is written for fully cooked deli roast beef. If you're slicing your own cooked roast, make sure the roast was cooked to a safe internal temperature of at least 145°F (63°C) with a 3-minute rest, per USDA guidance for whole beef cuts, before slicing thin.
Is this recipe gluten-free? ▼
Not as written, since it uses sourdough bread. Substitute a gluten-free sandwich bread of your choice and check that your horseradish and mayonnaise brands are labeled gluten-free.